Chromosomal Changes in Methylcholanthrene-induced Fibrosarcomas of the Mouse
نویسندگان
چکیده
منابع مشابه
Primary (methylcholanthrene-induced) fibrosarcomas and glycoprotein synthesis.
Paper-strip electrophoretic studies using tris(hydroxymethyl)aminomethane-ethylene diaminetetraacetic acid-boric acid buffer were carried out on the serum of rats bearing primary methylcholanthrene-induced fibrosarcomas as well as 1st and 2nd transplant generation autografts and isografts of such tumors. It was found that, though bearing histologically similar tumors, serum of different rats pr...
متن کاملPrimary (Methylcholanthrene-induced) Fibrosarcomas and Glycopro- tein Synthesis1
Paper-strip electrophoretic studies using tris(hydroxymethyl)aminomethane-ethylene diaminetetraacetic acid-boric acid buffer were carried out on the serum of rats bearing primary methylcholanthrene-induced fibrosarcomas as well as 1st and 2nd transplant generation autografts and isografts of such tumors. It was found that, though bearing histologically similar tumors, serum of different rats pr...
متن کاملMulticellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene
The cellular origin of tumors induced by the chemical carcinogen 3-methylcholanthrene (MCA) was studied in mice with X-chromosome inactivation mosaicism. Because only one of the two X-chromosomes is active in XX somatic cells, a female heterozygous at the X-linked phosphoglycerate kinase (PGK-1) locus for the usual Pgk-1b gene and the variant Pgk-1a has two populations of cells, in the cells of...
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15 صفحه اولEvidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.
Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1975
ISSN: 0021-4280
DOI: 10.2183/pjab1945.51.752